NGC 4121 is a dwarf elliptical galaxy in the constellation Draco.
"}{"fact":"In ancient Egypt, mummies were made of cats, and embalmed mice were placed with them in their tombs. In one ancient city, over 300,000 cat mummies were found.","length":158}
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{"slip": { "id": 224, "advice": "Don't drink bleach."}}
{"type":"standard","title":"Enclomifene","displaytitle":"Enclomifene","namespace":{"id":0,"text":""},"wikibase_item":"Q28208734","titles":{"canonical":"Enclomifene","normalized":"Enclomifene","display":"Enclomifene"},"pageid":12978453,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Enclomifene.svg/330px-Enclomifene.svg.png","width":320,"height":216},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/d/d0/Enclomifene.svg/720px-Enclomifene.svg.png","width":720,"height":485},"lang":"en","dir":"ltr","revision":"1279192625","tid":"e786a309-faf7-11ef-a3b7-b0822f339275","timestamp":"2025-03-07T02:00:12Z","description":"Chemical compound","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Enclomifene","revisions":"https://en.wikipedia.org/wiki/Enclomifene?action=history","edit":"https://en.wikipedia.org/wiki/Enclomifene?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Enclomifene"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Enclomifene","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Enclomifene","edit":"https://en.m.wikipedia.org/wiki/Enclomifene?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Enclomifene"}},"extract":"Enclomifene (INNTooltip International Nonproprietary Name), or enclomiphene (USANTooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and hence gonadal production of testosterone. It is one of the two stereoisomers of clomifene, which itself is a mixture of 38% zuclomifene and 62% enclomifene. Enclomifene is the (E)-stereoisomer of clomifene, while zuclomifene is the (Z)-stereoisomer. Whereas zuclomifene is more estrogenic, enclomifene is more antiestrogenic. In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the ER and reduces testosterone levels in men. As such, isomerically pure enclomifene is more favorable than clomifene as a progonadotropin for the treatment of male hypogonadism.","extract_html":"
Enclomifene (INNTooltip International Nonproprietary Name), or enclomiphene (USANTooltip United States Adopted Name), a nonsteroidal selective estrogen receptor modulator of the triphenylethylene group, acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen on the hypothalamic-pituitary-gonadal axis, thereby increasing gonadotropin secretion and hence gonadal production of testosterone. It is one of the two stereoisomers of clomifene, which itself is a mixture of 38% zuclomifene and 62% enclomifene. Enclomifene is the (E)-stereoisomer of clomifene, while zuclomifene is the (Z)-stereoisomer. Whereas zuclomifene is more estrogenic, enclomifene is more antiestrogenic. In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the ER and reduces testosterone levels in men. As such, isomerically pure enclomifene is more favorable than clomifene as a progonadotropin for the treatment of male hypogonadism.
"}